Efficacy, safety and patient-reported outcomes of combination etanercept and sulfasalazine versus etanercept alone in patients with rheumatoid arthritis: a double-blind randomised 2-year study
Identifieur interne : 001278 ( Main/Exploration ); précédent : 001277; suivant : 001279Efficacy, safety and patient-reported outcomes of combination etanercept and sulfasalazine versus etanercept alone in patients with rheumatoid arthritis: a double-blind randomised 2-year study
Auteurs : B. Combe [France] ; C. Codreanu [Roumanie] ; U. Fiocco [Italie] ; M. Gaubitz [Allemagne] ; P P Geusens [Belgique, Pays-Bas] ; T K Kvien [Norvège] ; K. Pavelka [République tchèque] ; P N Sambrook [Australie] ; J S Smolen [Autriche] ; R. Khandker [États-Unis] ; A. Singh [États-Unis] ; J. Wajdula [États-Unis] ; S. Fatenejad [États-Unis]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2008.
Abstract
To determine the efficacy and safety of etanercept and etanercept plus sulfasalazine versus sulfasalazine in patients with rheumatoid arthritis (RA) despite sulfasalazine therapy.
Patients were randomly assigned to etanercept (25 mg twice weekly; sulfasalazine was discontinued at baseline), etanercept plus sulfasalazine (unchanged regimen of 2–3 g/day) or sulfasalazine in a double-blind, randomised, 2-year study in adult patients with active RA despite sulfasalazine therapy. Efficacy was assessed using the American College of Rheumatology criteria, disease activity scores (DAS) and patient-reported outcomes (PRO).
Demographic variables and baseline disease characteristics were comparable among treatment groups; mean DAS 5.1, 5.2 and 5.1 for etanercept (n = 103), etanercept plus sulfasalazine (n = 101) and sulfasalazine (n = 50), respectively. Withdrawal due to lack of efficacy was highest with sulfasalazine (26 (52%) vs 6 (6%) for either etanercept group, p<0.001). Patients receiving etanercept or etanercept plus sulfasalazine had a more rapid initial response, which was sustained at 2 years, than those receiving sulfasalazine: mean DAS 2.8, 2.5 versus 4.5, respectively (p<0.05); ACR 20 response was achieved by 67%, 77% versus 34% of patients, respectively (p<0.01) Overall, PRO followed a similar pattern; a clinically significant improvement in health assessment questionnaire was achieved by 76%, 78% versus 40% of patients, respectively (p<0.01). Commonly reported adverse events occurring in the etanercept groups were injection site reactions and pharyngitis/laryngitis (p<0.01).
Etanercept and etanercept plus sulfasalazine are efficacious for the long-term management of patients with RA. The addition of etanercept or substitution with etanercept should be considered as treatment options for patients not adequately responding to sulfasalazine.
Url:
DOI: 10.1136/ard.2007.087106
PubMed: 18794178
PubMed Central: 2689524
Affiliations:
- Allemagne, Australie, Autriche, Belgique, France, Italie, Norvège, Pays-Bas, Roumanie, République tchèque, États-Unis
- Bohême centrale, Pennsylvanie, Vienne (Autriche)
- Montpellier, Prague, Sydney, Vienne (Autriche)
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Pavelka</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Institute of Rheumatology, Praha, Czech Republic</addr-line></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Rheumatology, Praha</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Sambrook, P N" sort="Sambrook, P N" uniqKey="Sambrook P" first="P N" last="Sambrook">P N Sambrook</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Kolling Institute, University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Kolling Institute, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J S" last="Smolen">J S Smolen</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>2nd Department of Medicine, Krankenhaus Lainz and Department of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>2nd Department of Medicine, Krankenhaus Lainz and Department of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Khandker, R" sort="Khandker, R" uniqKey="Khandker R" first="R" last="Khandker">R. Khandker</name><affiliation wicri:level="2"><nlm:aff id="aff11"><addr-line>Wyeth Research, Collegeville, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wyeth Research, Collegeville, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Singh, A" sort="Singh, A" uniqKey="Singh A" first="A" last="Singh">A. Singh</name><affiliation wicri:level="2"><nlm:aff id="aff11"><addr-line>Wyeth Research, Collegeville, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wyeth Research, Collegeville, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Wajdula, J" sort="Wajdula, J" uniqKey="Wajdula J" first="J" last="Wajdula">J. 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Fatenejad</name><affiliation wicri:level="2"><nlm:aff id="aff11"><addr-line>Wyeth Research, Collegeville, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wyeth Research, Collegeville, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18794178</idno><idno type="pmc">2689524</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689524</idno><idno type="RBID">PMC:2689524</idno><idno type="doi">10.1136/ard.2007.087106</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000319</idno><idno type="wicri:Area/Pmc/Curation">000319</idno><idno type="wicri:Area/Pmc/Checkpoint">000424</idno><idno type="wicri:Area/Ncbi/Merge">000040</idno><idno type="wicri:Area/Ncbi/Curation">000040</idno><idno type="wicri:Area/Ncbi/Checkpoint">000040</idno><idno type="wicri:doubleKey">0003-4967:2008:Combe B:efficacy:safety:and</idno><idno type="wicri:Area/Main/Merge">001281</idno><idno type="wicri:Area/Main/Curation">001278</idno><idno type="wicri:Area/Main/Exploration">001278</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy, safety and patient-reported outcomes of combination etanercept and sulfasalazine versus etanercept alone in patients with rheumatoid arthritis: a double-blind randomised 2-year study</title><author><name sortKey="Combe, B" sort="Combe, B" uniqKey="Combe B" first="B" last="Combe">B. Combe</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Service d'Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d'Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Codreanu, C" sort="Codreanu, C" uniqKey="Codreanu C" first="C" last="Codreanu">C. Codreanu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Centrul Metodologic de Reumatologie, Bucuresti, Romania</addr-line></nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Centrul Metodologic de Reumatologie, Bucuresti</wicri:regionArea><wicri:noRegion>Bucuresti</wicri:noRegion></affiliation></author><author><name sortKey="Fiocco, U" sort="Fiocco, U" uniqKey="Fiocco U" first="U" last="Fiocco">U. Fiocco</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Cattedra e Divisione di Reumatologia, Policlinico Universitario, Padova, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Cattedra e Divisione di Reumatologia, Policlinico Universitario, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Gaubitz, M" sort="Gaubitz, M" uniqKey="Gaubitz M" first="M" last="Gaubitz">M. Gaubitz</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Medical Clinic B Westfalian-Wilhelms-Univ, Munster, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Clinic B Westfalian-Wilhelms-Univ, Munster</wicri:regionArea><wicri:noRegion>Munster</wicri:noRegion><wicri:noRegion>Munster</wicri:noRegion><wicri:noRegion>Munster</wicri:noRegion></affiliation></author><author><name sortKey="Geusens, P P" sort="Geusens, P P" uniqKey="Geusens P" first="P P" last="Geusens">P P Geusens</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Biomedical Research Center, University Hasselt, Hasselt, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Biomedical Research Center, University Hasselt, Hasselt</wicri:regionArea><wicri:noRegion>Hasselt</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Department of Internal Medicine/Rheumatology, University Maastricht, Maastricht, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine/Rheumatology, University Maastricht, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Kvien, T K" sort="Kvien, T K" uniqKey="Kvien T" first="T K" last="Kvien">T K Kvien</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Department of Rheumatology, Diakonhjemmets Hospital, Oslo, Norway</addr-line></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Rheumatology, Diakonhjemmets Hospital, Oslo</wicri:regionArea><wicri:noRegion>Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Pavelka, K" sort="Pavelka, K" uniqKey="Pavelka K" first="K" last="Pavelka">K. Pavelka</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Institute of Rheumatology, Praha, Czech Republic</addr-line></nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Rheumatology, Praha</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Sambrook, P N" sort="Sambrook, P N" uniqKey="Sambrook P" first="P N" last="Sambrook">P N Sambrook</name><affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Kolling Institute, University of Sydney, Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Kolling Institute, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J S" last="Smolen">J S Smolen</name><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>2nd Department of Medicine, Krankenhaus Lainz and Department of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>2nd Department of Medicine, Krankenhaus Lainz and Department of Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Khandker, R" sort="Khandker, R" uniqKey="Khandker R" first="R" last="Khandker">R. Khandker</name><affiliation wicri:level="2"><nlm:aff id="aff11"><addr-line>Wyeth Research, Collegeville, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wyeth Research, Collegeville, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Singh, A" sort="Singh, A" uniqKey="Singh A" first="A" last="Singh">A. Singh</name><affiliation wicri:level="2"><nlm:aff id="aff11"><addr-line>Wyeth Research, Collegeville, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wyeth Research, Collegeville, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Wajdula, J" sort="Wajdula, J" uniqKey="Wajdula J" first="J" last="Wajdula">J. Wajdula</name><affiliation wicri:level="2"><nlm:aff id="aff11"><addr-line>Wyeth Research, Collegeville, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wyeth Research, Collegeville, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Fatenejad, S" sort="Fatenejad, S" uniqKey="Fatenejad S" first="S" last="Fatenejad">S. Fatenejad</name><affiliation wicri:level="2"><nlm:aff id="aff11"><addr-line>Wyeth Research, Collegeville, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wyeth Research, Collegeville, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Annals of the Rheumatic Diseases</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To determine the efficacy and safety of etanercept and etanercept plus sulfasalazine versus sulfasalazine in patients with rheumatoid arthritis (RA) despite sulfasalazine therapy.</p></sec><sec><title>Methods:</title><p>Patients were randomly assigned to etanercept (25 mg twice weekly; sulfasalazine was discontinued at baseline), etanercept plus sulfasalazine (unchanged regimen of 2–3 g/day) or sulfasalazine in a double-blind, randomised, 2-year study in adult patients with active RA despite sulfasalazine therapy. Efficacy was assessed using the American College of Rheumatology criteria, disease activity scores (DAS) and patient-reported outcomes (PRO).</p></sec><sec><title>Results:</title><p>Demographic variables and baseline disease characteristics were comparable among treatment groups; mean DAS 5.1, 5.2 and 5.1 for etanercept (n = 103), etanercept plus sulfasalazine (n = 101) and sulfasalazine (n = 50), respectively. Withdrawal due to lack of efficacy was highest with sulfasalazine (26 (52%) vs 6 (6%) for either etanercept group, p<0.001). Patients receiving etanercept or etanercept plus sulfasalazine had a more rapid initial response, which was sustained at 2 years, than those receiving sulfasalazine: mean DAS 2.8, 2.5 versus 4.5, respectively (p<0.05); ACR 20 response was achieved by 67%, 77% versus 34% of patients, respectively (p<0.01) Overall, PRO followed a similar pattern; a clinically significant improvement in health assessment questionnaire was achieved by 76%, 78% versus 40% of patients, respectively (p<0.01). Commonly reported adverse events occurring in the etanercept groups were injection site reactions and pharyngitis/laryngitis (p<0.01).</p></sec><sec><title>Conclusion:</title><p>Etanercept and etanercept plus sulfasalazine are efficacious for the long-term management of patients with RA. The addition of etanercept or substitution with etanercept should be considered as treatment options for patients not adequately responding to sulfasalazine.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="O Ell, Jr" uniqKey="O Ell J">JR O’Dell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furst, De" uniqKey="Furst D">DE Furst</name></author><author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name></author><author><name sortKey="Kalden, Jr" uniqKey="Kalden J">JR Kalden</name></author><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Burmester, Gr" uniqKey="Burmester G">GR Burmester</name></author><author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinblatt, Me" uniqKey="Weinblatt M">ME Weinblatt</name></author><author><name sortKey="Kremer, Jm" uniqKey="Kremer J">JM Kremer</name></author><author><name sortKey="Bankhurst, Ad" uniqKey="Bankhurst A">AD Bankhurst</name></author><author><name sortKey="Bulpitt, Kj" uniqKey="Bulpitt K">KJ Bulpitt</name></author><author><name sortKey="Fleischmann, Rm" uniqKey="Fleischmann R">RM Fleischmann</name></author><author><name sortKey="Fox, Ri" uniqKey="Fox R">RI Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maini, R" uniqKey="Maini R">R Maini</name></author><author><name sortKey="St Clair, Ew" uniqKey="St Clair E">EW St Clair</name></author><author><name sortKey="Breedveld, F" uniqKey="Breedveld F">F Breedveld</name></author><author><name sortKey="Furst, D" uniqKey="Furst D">D Furst</name></author><author><name sortKey="Kalden, J" uniqKey="Kalden J">J Kalden</name></author><author><name sortKey="Weisman, M" uniqKey="Weisman M">M Weisman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsumoto, I" uniqKey="Matsumoto I">I Matsumoto</name></author><author><name sortKey="Lee, Dm" uniqKey="Lee D">DM Lee</name></author><author><name sortKey="Goldbach Mansky, R" uniqKey="Goldbach Mansky R">R Goldbach-Mansky</name></author><author><name sortKey="Sumida, T" uniqKey="Sumida T">T Sumida</name></author><author><name sortKey="Hitchon, Ca" uniqKey="Hitchon C">CA Hitchon</name></author><author><name sortKey="Schur, Ph" uniqKey="Schur P">PH Schur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maini, Rn" uniqKey="Maini R">RN Maini</name></author><author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name></author><author><name sortKey="Kalden, Jr" uniqKey="Kalden J">JR Kalden</name></author><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Davis, D" uniqKey="Davis D">D Davis</name></author><author><name sortKey="Macfarlane, Jd" uniqKey="Macfarlane J">JD Macfarlane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weisman, Mh" uniqKey="Weisman M">MH Weisman</name></author><author><name sortKey="Moreland, Lw" uniqKey="Moreland L">LW Moreland</name></author><author><name sortKey="Furst, De" uniqKey="Furst D">DE Furst</name></author><author><name sortKey="Weinblatt, Me" uniqKey="Weinblatt M">ME Weinblatt</name></author><author><name sortKey="Keystone, Ec" uniqKey="Keystone E">EC Keystone</name></author><author><name sortKey="Paulus, He" uniqKey="Paulus H">HE Paulus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bankhurst, Ad" uniqKey="Bankhurst A">AD Bankhurst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furst, De" uniqKey="Furst D">DE Furst</name></author><author><name sortKey="Schiff, Mh" uniqKey="Schiff M">MH Schiff</name></author><author><name sortKey="Fleischmann, Rm" uniqKey="Fleischmann R">RM Fleischmann</name></author><author><name sortKey="Strand, V" uniqKey="Strand V">V Strand</name></author><author><name sortKey="Birbara, Ca" uniqKey="Birbara C">CA Birbara</name></author><author><name sortKey="Compagnone, D" uniqKey="Compagnone D">D Compagnone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Combe, B" uniqKey="Combe B">B Combe</name></author><author><name sortKey="Codreanu, C" uniqKey="Codreanu C">C Codreanu</name></author><author><name sortKey="Fiocco, U" uniqKey="Fiocco U">U Fiocco</name></author><author><name sortKey="Gaubitz, M" uniqKey="Gaubitz M">M Gaubitz</name></author><author><name sortKey="Geusens, Pp" uniqKey="Geusens P">PP Geusens</name></author><author><name sortKey="Kvien, Tk" uniqKey="Kvien T">TK Kvien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burmester, Gr" uniqKey="Burmester G">GR Burmester</name></author><author><name sortKey="Mariette, X" uniqKey="Mariette X">X Mariette</name></author><author><name sortKey="Montecucco, C" uniqKey="Montecucco C">C Montecucco</name></author><author><name sortKey="Monteagudo Saez, I" uniqKey="Monteagudo Saez I">I Monteagudo-Saez</name></author><author><name sortKey="Malaise, M" uniqKey="Malaise M">M Malaise</name></author><author><name sortKey="Tzioufas, Ag" uniqKey="Tzioufas A">AG Tzioufas</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Anderson, Jj" uniqKey="Anderson J">JJ Anderson</name></author><author><name sortKey="Boers, M" uniqKey="Boers M">M Boers</name></author><author><name sortKey="Bombardier, C" uniqKey="Bombardier C">C Bombardier</name></author><author><name sortKey="Furst, D" uniqKey="Furst D">D Furst</name></author><author><name sortKey="Goldsmith, C" uniqKey="Goldsmith C">C Goldsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruce, B" uniqKey="Bruce B">B Bruce</name></author><author><name sortKey="Fries, Jf" uniqKey="Fries J">JF Fries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardiner, Pv" uniqKey="Gardiner P">PV Gardiner</name></author><author><name sortKey="Sykes, Hr" uniqKey="Sykes H">HR Sykes</name></author><author><name sortKey="Hassey, Ga" uniqKey="Hassey G">GA Hassey</name></author><author><name sortKey="Walker, Dj" uniqKey="Walker D">DJ Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurst, Np" uniqKey="Hurst N">NP Hurst</name></author><author><name sortKey="Kind, P" uniqKey="Kind P">P Kind</name></author><author><name sortKey="Ruta, D" uniqKey="Ruta D">D Ruta</name></author><author><name sortKey="Hunter, M" uniqKey="Hunter M">M Hunter</name></author><author><name sortKey="Stubbings, A" uniqKey="Stubbings A">A Stubbings</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kind, P" uniqKey="Kind P">P Kind</name></author><author><name sortKey="Hardman, G" uniqKey="Hardman G">G Hardman</name></author><author><name sortKey="Macran, S" uniqKey="Macran S">S Macran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keystone, Ec" uniqKey="Keystone E">EC Keystone</name></author><author><name sortKey="Kavanaugh, Af" uniqKey="Kavanaugh A">AF Kavanaugh</name></author><author><name sortKey="Sharp, Jt" uniqKey="Sharp J">JT Sharp</name></author><author><name sortKey="Tannenbaum, H" uniqKey="Tannenbaum H">H Tannenbaum</name></author><author><name sortKey="Hua, Y" uniqKey="Hua Y">Y Hua</name></author><author><name sortKey="Teoh, Ls" uniqKey="Teoh L">LS Teoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Riel, Pl" uniqKey="Van Riel P">PL van Riel</name></author><author><name sortKey="Taggart, Aj" uniqKey="Taggart A">AJ Taggart</name></author><author><name sortKey="Sany, J" uniqKey="Sany J">J Sany</name></author><author><name sortKey="Gaubitz, M" uniqKey="Gaubitz M">M Gaubitz</name></author><author><name sortKey="Nab, Hw" uniqKey="Nab H">HW Nab</name></author><author><name sortKey="Pedersen, R" uniqKey="Pedersen R">R Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krishnan, E" uniqKey="Krishnan E">E Krishnan</name></author><author><name sortKey="Sokka, T" uniqKey="Sokka T">T Sokka</name></author><author><name sortKey="Hakkinen, A" uniqKey="Hakkinen A">A Hakkinen</name></author><author><name sortKey="Hubert, H" uniqKey="Hubert H">H Hubert</name></author><author><name sortKey="Hannonen, P" uniqKey="Hannonen P">P Hannonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wells, Ga" uniqKey="Wells G">GA Wells</name></author><author><name sortKey="Tugwell, P" uniqKey="Tugwell P">P Tugwell</name></author><author><name sortKey="Kraag, Gr" uniqKey="Kraag G">GR Kraag</name></author><author><name sortKey="Baker, Pr" uniqKey="Baker P">PR Baker</name></author><author><name sortKey="Groh, J" uniqKey="Groh J">J Groh</name></author><author><name sortKey="Redelmeier, Da" uniqKey="Redelmeier D">DA Redelmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drossaers Bakker, Kw" uniqKey="Drossaers Bakker K">KW Drossaers-Bakker</name></author><author><name sortKey="De Buck, M" uniqKey="De Buck M">M de Buck</name></author><author><name sortKey="Van Zeben, D" uniqKey="Van Zeben D">D van Zeben</name></author><author><name sortKey="Zwinderman, Ah" uniqKey="Zwinderman A">AH Zwinderman</name></author><author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name></author><author><name sortKey="Hazes, Jm" uniqKey="Hazes J">JM Hazes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jansen, Lm" uniqKey="Jansen L">LM Jansen</name></author><author><name sortKey="Van Schaardenburg, D" uniqKey="Van Schaardenburg D">D van Schaardenburg</name></author><author><name sortKey="Van Der Horst Bruinsma, Ie" uniqKey="Van Der Horst Bruinsma I">IE van Der Horst-Bruinsma</name></author><author><name sortKey="Bezemer, Pd" uniqKey="Bezemer P">PD Bezemer</name></author><author><name sortKey="Dijkmans, Ba" uniqKey="Dijkmans B">BA Dijkmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Heijde, D" uniqKey="Van Der Heijde D">D van der Heijde</name></author><author><name sortKey="Landewe, R" uniqKey="Landewe R">R Landewe</name></author><author><name sortKey="Van Vollenhoven, R" uniqKey="Van Vollenhoven R">R van Vollenhoven</name></author><author><name sortKey="Fatenejad, S" uniqKey="Fatenejad S">S Fatenejad</name></author><author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L Klareskog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Odegard, S" uniqKey="Odegard S">S Odegard</name></author><author><name sortKey="Landewe, R" uniqKey="Landewe R">R Landewe</name></author><author><name sortKey="Van Der Heijde, D" uniqKey="Van Der Heijde D">D van der Heijde</name></author><author><name sortKey="Kvien, Tk" uniqKey="Kvien T">TK Kvien</name></author><author><name sortKey="Mowinckel, P" uniqKey="Mowinckel P">P Mowinckel</name></author><author><name sortKey="Uhlig, T" uniqKey="Uhlig T">T Uhlig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eriksson, C" uniqKey="Eriksson C">C Eriksson</name></author><author><name sortKey="Engstrand, S" uniqKey="Engstrand S">S Engstrand</name></author><author><name sortKey="Sundqvist, Kg" uniqKey="Sundqvist K">KG Sundqvist</name></author><author><name sortKey="Rantapaa Dahlqvist, S" uniqKey="Rantapaa Dahlqvist S">S 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sortKey="Banchereau, J" uniqKey="Banchereau J">J Banchereau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoels, M" uniqKey="Schoels M">M Schoels</name></author><author><name sortKey="Kapral, T" uniqKey="Kapral T">T Kapral</name></author><author><name sortKey="Stamm, T" uniqKey="Stamm T">T Stamm</name></author><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Kooij, Sm" uniqKey="Van Der Kooij S">SM van der Kooij</name></author><author><name sortKey="De Vries Bouwstra, Jk" uniqKey="De Vries Bouwstra J">JK de Vries-Bouwstra</name></author><author><name sortKey="Goekoop Ruiterman, Yp" uniqKey="Goekoop Ruiterman Y">YP Goekoop-Ruiterman</name></author><author><name sortKey="Van Zeben, D" uniqKey="Van Zeben D">D van Zeben</name></author><author><name sortKey="Kerstens, 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Combe</name></noRegion></country><country name="Roumanie"><noRegion><name sortKey="Codreanu, C" sort="Codreanu, C" uniqKey="Codreanu C" first="C" last="Codreanu">C. Codreanu</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Fiocco, U" sort="Fiocco, U" uniqKey="Fiocco U" first="U" last="Fiocco">U. Fiocco</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Gaubitz, M" sort="Gaubitz, M" uniqKey="Gaubitz M" first="M" last="Gaubitz">M. Gaubitz</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Geusens, P P" sort="Geusens, P P" uniqKey="Geusens P" first="P P" last="Geusens">P P Geusens</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Geusens, P P" sort="Geusens, P P" uniqKey="Geusens P" first="P P" last="Geusens">P P Geusens</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Kvien, T K" sort="Kvien, T K" uniqKey="Kvien T" first="T K" last="Kvien">T K Kvien</name></noRegion></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Pavelka, K" sort="Pavelka, K" uniqKey="Pavelka K" first="K" last="Pavelka">K. Pavelka</name></region></country><country name="Australie"><noRegion><name sortKey="Sambrook, P N" sort="Sambrook, P N" uniqKey="Sambrook P" first="P N" last="Sambrook">P N Sambrook</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Smolen, J S" sort="Smolen, J S" uniqKey="Smolen J" first="J S" last="Smolen">J S Smolen</name></region></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Khandker, R" sort="Khandker, R" uniqKey="Khandker R" first="R" last="Khandker">R. Khandker</name></region><name sortKey="Fatenejad, S" sort="Fatenejad, S" uniqKey="Fatenejad S" first="S" last="Fatenejad">S. Fatenejad</name><name sortKey="Singh, A" sort="Singh, A" uniqKey="Singh A" first="A" last="Singh">A. Singh</name><name sortKey="Wajdula, J" sort="Wajdula, J" uniqKey="Wajdula J" first="J" last="Wajdula">J. Wajdula</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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